Journal of Global Infectious Diseases

MICROBIOLOGY REPORT
Year
: 2018  |  Volume : 10  |  Issue : 1  |  Page : 19--21

Nitrofurantoin and Fosfomycin for Extended Spectrum Beta-lactamases Producing Escherichia coli and Klebsiella pneumoniae


Neeraj Kumar Tulara 
 Department of Infectious Disease, Dr L H Hiranandani Hospital, Mumbai, Maharashtra, India

Correspondence Address:
Dr. Neeraj Kumar Tulara
Department of Infectious Disease, Dr L H Hiranandani Hospital, Central Avenue, Powai, Mumbai, Maharashtra
India

Urinary tract infection (UTI) is a common and painful human illness that, unfortunately not responsive to commonly used antibiotics in current practice. The role of fosfomycin and nitrofurantoin in the era of growing bacteria resistance has been widely discussed. In this study, we aimed to know the local antimicrobial susceptibilities, fosfomycin and nitrofurantoin susceptibility in particular, for urinary extended-spectrum-beta-lactamase-producing Escherichia coli and Escherichia pneumoniae (ESBL-EC and ESBL-KP) isolates in our hospital. We collected 464 urine isolates, including 384 ESBL-EC and 80 ESBL-KP isolates. Of 464 urine isolates culture positive ESBL-UTIs, EC caused 384 (82.75%), followed by Klebsiella in 80 (17.24%). Carbapenems and Colistin seems to remain as the first line therapy for the majority of ESBL-UTIs in the local setting. Colistin and fosfomycin remains the most sensitive antibiotic while nitrofurantoin still preserves the good sensitivity against ESBL and found to be an only oral sensitive antibiotic.


How to cite this article:
Tulara NK. Nitrofurantoin and Fosfomycin for Extended Spectrum Beta-lactamases Producing Escherichia coli and Klebsiella pneumoniae.J Global Infect Dis 2018;10:19-21


How to cite this URL:
Tulara NK. Nitrofurantoin and Fosfomycin for Extended Spectrum Beta-lactamases Producing Escherichia coli and Klebsiella pneumoniae. J Global Infect Dis [serial online] 2018 [cited 2021 Dec 6 ];10:19-21
Available from: https://www.jgid.org/article.asp?issn=0974-777X;year=2018;volume=10;issue=1;spage=19;epage=21;aulast=Tulara;type=0