LETTER TO EDITOR
Year : 2013 | Volume
: 5 | Issue : 3 | Page : 121-
Serological evaluation of leptospirosis: A report from western India
Dnyaneshwari P Ghadage, Vrishali A Muley, Arvind V Bhore
Department of Microbiology, Smt. Kashibai Navale Medical College and General Hospital, Survey No. 49/1, 53/2, Off Mumbai-Pune Bypass, Narhe Ambegaon (Bk), Pune, Maharashtra, India
Vrishali A Muley
Department of Microbiology, Smt. Kashibai Navale Medical College and General Hospital, Survey No. 49/1, 53/2, Off Mumbai-Pune Bypass, Narhe Ambegaon (Bk), Pune, Maharashtra
|How to cite this article:|
Ghadage DP, Muley VA, Bhore AV. Serological evaluation of leptospirosis: A report from western India.J Global Infect Dis 2013;5:121-121
|How to cite this URL:|
Ghadage DP, Muley VA, Bhore AV. Serological evaluation of leptospirosis: A report from western India. J Global Infect Dis [serial online] 2013 [cited 2020 Oct 31 ];5:121-121
Available from: https://www.jgid.org/text.asp?2013/5/3/121/116877
Leptospirosis is a zoonotic disease with humans getting the infection either from rodent hosts or from domestic animals. , The disease, if not diagnosed and treated at an early stage, can cause fatal complications. Hence, early confirmation of the diagnosis improves the prognosis. 
In the present study, serological evaluation of human subjects suspected of leptospirosis was done. Serological tests used were Leptotek Dri-Dot test, IgM ELISA and MAT either in combination or singly.
A total of 882 serum samples were received in the Regional Diagnostic Centre during one year period. Out of 25.1% samples processed by Dri-Dot test, 11.2% were positive by Dri-Dot test. IgM ELISA was performed on 585 (66.3%) samples. 37% of these were positive by IgM ELISA. Fifty samples were tested by both the tests, Dri-Dot and IgM ELISA. 36% samples were positive by both the tests. 16% were positive by Dri-Dot but negative by IgM ELISA. 2% samples were negative by Dr-Dot but positive by IgM ELISA. 25 samples were subjected to MAT, out of which 44% were positive by MAT. Icterohaemorrhagiae was found to be the predominant serovar.
Dri-Dot test is sensitive, rapid and easy to perform. However, it is less specific than IgM ELISA. Hence,
Dri-Dot test can be used at periphery where facility for ELISA is not available. In a hospital scenario, laboratory diagnosis should be done by ELISA.
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