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Year : 2015  |  Volume : 7  |  Issue : 1  |  Page : 44-45
Elbow Mycobacterium Tuberculosis in America

1 Department of Infection Control, Coordinated Health, Bethlehem, PA 18020, USA
2 Department of Clinical Education and Research, Coordinated Health, Bethlehem, PA 18020, USA
3 Department of Infectious Disease, Coordinated Health, Bethlehem, PA 18020, USA
4 Department of Orthopedics, Coordinated Health, Bethlehem, PA 18020, USA

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Date of Web Publication5-Feb-2015

How to cite this article:
Novatnack ES, Protzman NM, Kannangara S, Busch MF. Elbow Mycobacterium Tuberculosis in America. J Global Infect Dis 2015;7:44-5

How to cite this URL:
Novatnack ES, Protzman NM, Kannangara S, Busch MF. Elbow Mycobacterium Tuberculosis in America. J Global Infect Dis [serial online] 2015 [cited 2021 Oct 20];7:44-5. Available from:


Less than 1% of tuberculosis (TB) cases are specific to the elbow. [1],[2] Symptoms often develop insidiously, and in the absence of pulmonary involvement, TB is typically excluded from the differential diagnosis.

A 69-year-old man, originally from Pakistan, presented with elbow swelling, pain, and decreased range of motion. His medical history included dengue, entamoeba histolytica, and gout. He reported recent unexplained changes in weight, weakness and fatigue, loss of appetite, changes in skin, blurred vision, coughing, smoking, abdominal pain, frequent diarrhea, and constipation. Vital signs were within normal limits. There was no skin breakdown or lesions. The elbow demonstrated diffuse swelling, but no redness. Radiographs revealed mild osteoarthritis, but no acute fractures.

The elbow joint was aspirated without complication. The patient was negative for rheumatoid factor and lyme disease. The C-reactive protein was within normal limits, and the sedimentation rate was 29 mm/h.

Despite no trauma, 6 months later, the patient reported increased swelling, pain, and decreased range of motion. The elbow demonstrated moderate effusion and some warmth, but no ecchymosis. Radiographs showed increased erosion of the capitellum and radial head, but no acute fractures or subluxation.

The joint was aspirated without complication. No aerobic growth or crystals were seen. Given the worsening symptoms, the patient was admitted for incision and drainage of the right elbow and olecranon bursa. Tissue, bone, and fluid specimens were obtained.

Pulmonary TB was ruled out. Acid-fast Bacilli (AFB) cultures were obtained for all surgical specimens. The primary culture media included a Remel Mitchison 7H11 Selective Agar Slant (Thermo Scientific Remel , Waltham, MA) and a VersaTREK ® Myco liquid medium (TREK Diagnostic Systems, Oakwood Village, OH). Growth was present on the slant and in the liquid medium. Both the agar slant and the liquid medium were Kinyoun positive.

Twelve days after the specimen was submitted; Mycobacterium probes were tested on the culture. The Mycobacterium TB (MTB) probe was positive, and the Mycobacterium avium probe was negative.

The mycobacteria were sub-cultured to Lowenstein-Jensen agar slants (Thermo Scientific Remel , Waltham, MA) and Middlebrook 7H10 agar plates (Thermo Scientific Remel , Waltham, MA). A Lowenstein-Jensen slant was sent to the Pennsylvania Department of Health Bureau of Laboratories for further identification and susceptibility testing. By high-performance liquid chromatography, the isolate was identified as MTB complex. The MTB isolate was susceptible to all drugs tested (isoniazid [0.1 and 0.4 μg/mL], ethambutol [5.0 μg/mL], rifampin [1.0 μg/mL], and pyrazinamide [100 μg/mL]).

Although TB control has dramatically improved, the proportion of extra-pulmonary cases in the United States has progressively increased from 16% in 1993 to 21% in 2012. [3] The female gender, nonwhite race and/or ethnicity, foreign birth, and positive HIV status have emerged as risk factors. [4],[5]

In the present report, the patient presented with elbow pain, soft tissue swelling, and reduced function. He was of nonwhite race, born outside of the United States, and was positive for recent weight loss. The authors advocate the consideration of AFB cultures in cases of monoarticular chronic inflammation to facilitate prompt diagnosis and limit morbidity and mortality.

   References Top

Chen WS, Wang CJ, Eng HL. Tuberculous arthritis of the elbow. Int Orthop 1997;21:367-70.  Back to cited text no. 1
Aggarwal A, Dhammi I. Clinical and radiological presentation of tuberculosis of the elbow. Acta Orthop Belg 2006;72:282-7.  Back to cited text no. 2
CDC. Reported Tuberculosis in the United States, 2012. Atlanta, GA: U.S. Department of Health and Human Services, CDC; 2013. Available from: [Last accessed on 2014 Jun 16].  Back to cited text no. 3
Yang Z, Kong Y, Wilson F, Foxman B, Fowler AH, Marrs CF, et al. Identification of risk factors for extrapulmonary tuberculosis. Clin Infect Dis 2004;38:199-205.  Back to cited text no. 4
Peto HM, Pratt RH, Harrington TA, LoBue PA, Armstrong LR. Epidemiology of extrapulmonary tuberculosis in the United States, 1993-2006. Clin Infect Dis 2009;49:1350-7.  Back to cited text no. 5

Correspondence Address:
Nicole M Protzman
Department of Clinical Education and Research, Coordinated Health, Bethlehem, PA 18020
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0974-777X.146374

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2008 Journal of Global Infectious Diseases | Published by Wolters Kluwer - Medknow
Online since 10th December, 2008