Journal of Global Infectious Diseases

ORIGINAL ARTICLE
Year
: 2011  |  Volume : 3  |  Issue : 3  |  Page : 269--274

HIV, hepatitis B, and hepatitis C in Zambia


Kenneth C Kapembwa1, Jason D Goldman2, Shabir Lakhi1, Yolan Banda4, Kasonde Bowa3, Sten H Vermund4, Joseph Mulenga5, David Chama5, Benjamin H Chi6 
1 Department of Internal Medicine, School of Medicine, University of Zambia; Department of Internal Medicine, University Teaching Hospital, Lusaka, Zambia
2 Department of Medicine, School of Medicine, University of Washington, Seattle, WA, USA; Centre for Infectious Disease Research in Zambia, Lusaka, Zambia
3 Department of Surgery, School of Medicine, University Teaching Hospital, Lusaka, Zambia
4 Centre for Infectious Disease Research in Zambia, Lusaka, Zambia; Institute of Global Health and Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, USA
5 Zambia National Blood Transfusion Service, Lusaka, Zambia
6 Centre for Infectious Disease Research in Zambia, Lusaka, Zambia; Department of Obstetrics and Gynecology, School of Medicine, University of Alabama, Birmingham, AL, USA

Correspondence Address:
Kenneth C Kapembwa
Department of Internal Medicine, School of Medicine, University of Zambia; Department of Internal Medicine, University Teaching Hospital, Lusaka, Zambia

Objectives : Epidemiologic data of HIV and viral hepatitis coinfection are needed in sub-Saharan Africa to guide health policy for hepatitis screening and optimized antiretroviral therapy (ART). Materials and Methods: We screened 323 HIV-infected, ART-eligible adults for hepatitis B surface antigen (HBsAg) and hepatitis C antibody (HCV Ab) at a tertiary hospital in Lusaka, Zambia. We collected basic demographic, medical, and laboratory data to determine predictors for coinfection. Results: Of 323 enrolled patients, 32 (9.9%; 95% CI=6.7-13.2%) were HBsAg positive, while 4 (1.2%; 95% CI=0.03-2.4%) were HCV Ab positive. Patients with hepatitis B coinfection were more likely to be <40 years (84.4% vs. 61.4%; P=0.01) when compared to those who were not coinfected. Patients with active hepatitis B were more likely to have mild to moderately elevated AST/ALT (40-199 IU/L, 15.8% vs. 5.4%; P=0.003). Highly elevated liver enzymes (>200 IU/L) was uncommon and did not differ between the two groups (3.4% vs. 2.3%; P=0.5). We were unable to determine predictors of hepatitis C infection due to the low prevalence of disease. Conclusions: HIV and hepatitis B coinfection was common among patients initiating ART at this tertiary care facility. Routine screening for hepatitis B should be considered for HIV-infected persons in southern Africa.


How to cite this article:
Kapembwa KC, Goldman JD, Lakhi S, Banda Y, Bowa K, Vermund SH, Mulenga J, Chama D, Chi BH. HIV, hepatitis B, and hepatitis C in Zambia.J Global Infect Dis 2011;3:269-274


How to cite this URL:
Kapembwa KC, Goldman JD, Lakhi S, Banda Y, Bowa K, Vermund SH, Mulenga J, Chama D, Chi BH. HIV, hepatitis B, and hepatitis C in Zambia. J Global Infect Dis [serial online] 2011 [cited 2019 Oct 17 ];3:269-274
Available from: http://www.jgid.org/article.asp?issn=0974-777X;year=2011;volume=3;issue=3;spage=269;epage=274;aulast=Kapembwa;type=0