Journal of Global Infectious Diseases

ORIGINAL ARTICLE
Year
: 2011  |  Volume : 3  |  Issue : 2  |  Page : 133--137

Potential activity of the purine compounds caffeine and aminophylline on bacteria


Ali Abdul Hussein S AL-Janabi 
 Department of Clinical Laboratory, College of Applicable of Medical Sciences, University of Karbala, Iraq

Correspondence Address:
Ali Abdul Hussein S AL-Janabi
Department of Clinical Laboratory, College of Applicable of Medical Sciences, University of Karbala
Iraq

Background: Purine compounds are special types of alkaloids. Caffeine and aminophylline are considered the most important members of purines due to their wide use in therapeutics. Aims: To detect any potential antibacterial effects on pathogenic bacteria of the widely prescribed members of purines caffeine and aminophylline. Materials and Methods: Two species of gram-positive bacteria and five species of gram-negative bacteria were exposed to these purine agents. Antibacterial effects of the tested purines were determined using the spectrophotometer method to assess the minimum inhibition concentrations (MIC). Results: Among the strains of bacteria tested, Bacillus subtilis showed the most susceptibility to purine agents. Staphylococcus aureus and Bacillus subtilis were found to be more susceptible to caffeine than the other strains. Aminophylline showed inhibitory action on many isolates, especially at the concentration of 10mg/ml. Paracoccus yeei demonstrated resistance to all tested purine compounds up to a concentration of 10.5mg/ml. Conclusions: Caffeine and aminophylline had the ability to inhibit many strains of pathogenic bacteria.


How to cite this article:
AL-Janabi AS. Potential activity of the purine compounds caffeine and aminophylline on bacteria.J Global Infect Dis 2011;3:133-137


How to cite this URL:
AL-Janabi AS. Potential activity of the purine compounds caffeine and aminophylline on bacteria. J Global Infect Dis [serial online] 2011 [cited 2020 Sep 22 ];3:133-137
Available from: http://www.jgid.org/article.asp?issn=0974-777X;year=2011;volume=3;issue=2;spage=133;epage=137;aulast=AL-Janabi;type=0