Journal of Global Infectious Diseases

SYMPOSIUM ON INFECTIOUS AGENTS IN A MULTIDRUG RESISTANT GLOBE
Year
: 2010  |  Volume : 2  |  Issue : 3  |  Page : 258--262

Quinolone and cephalosporin resistance in enteric fever


Malini Rajinder Capoor, Deepthi Nair 
 Department of Microbiology, Vardhman Mahaveer Medical College and Safdarjung Hospital, New Delhi, India

Correspondence Address:
Malini Rajinder Capoor
Department of Microbiology, Vardhman Mahaveer Medical College and Safdarjung Hospital, New Delhi
India

Enteric fever is a major public health problem in developing countries. Ciprofloxacin resistance has now become a norm in the Indian subcontinent. Novel molecular substitutions may become frequent in future owing to selective pressures exerted by the irrational use of ciprofloxacin in human and veterinary therapeutics, in a population endemic with nalidixic acid-resistant strains. The therapeutics of ciprofloxacin-resistant enteric fever narrows down to third- and fourth-generation cephalosporins, azithromycin, tigecycline and penems. The first-line antimicrobials ampicillin, chloramphenicol and co-trimoxazole need to be rolled back. Antimicrobial surveillance coupled with molecular analysis of fluoroquinolone resistance is warranted for reconfirming novel and established molecular patterns for therapeutic reappraisal and for novel-drug targets. This review explores the antimicrobial resistance and its molecular mechanisms, as well as novel drugs in the therapy of enteric fever.


How to cite this article:
Capoor MR, Nair D. Quinolone and cephalosporin resistance in enteric fever.J Global Infect Dis 2010;2:258-262


How to cite this URL:
Capoor MR, Nair D. Quinolone and cephalosporin resistance in enteric fever. J Global Infect Dis [serial online] 2010 [cited 2019 Sep 16 ];2:258-262
Available from: http://www.jgid.org/article.asp?issn=0974-777X;year=2010;volume=2;issue=3;spage=258;epage=262;aulast=Capoor;type=0