Journal of Global Infectious DiseasesOfficial Publishing of INDUSEM and OPUS 12 Foundation, Inc. Users online:793  
Print this pageEmail this pageSmall font sizeDefault font sizeIncrease font size     
Home About us Editors Ahead of Print Current Issue Archives Search Instructions Subscribe Advertise Login 
 
ORIGINAL ARTICLE
Year : 2018  |  Volume : 10  |  Issue : 2  |  Page : 99-107

Leprosy-associated chronic wound management using biomaterials


1 Department of Virology, King Institute of Preventive Medicine and Research, Chennai, Tamil Nadu, India
2 Center for Environmental Research and Development, LIFE, Loyola College, Chennai, Tamil Nadu, India
3 Department of Virology, King Institute of Preventive Medicine and Research; CSIR-Central Leather Research Institute, Chennai, Tamil Nadu, India
4 Department of Virology, King Institute of Preventive Medicine and Research, Chennai, Tamil Nadu; Institute for Healthcare Education and Translational Sciences (IHETS), Hyderabad, Telengana, India
5 Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Sweden
6 CSIR-Central Leather Research Institute, Chennai, Tamil Nadu, India
7 Institute for Healthcare Education and Translational Sciences (IHETS), Hyderabad, Telengana, India; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Sweden

Correspondence Address:
Dr. Satish S Kitambi
Department of Microbiology, Tumor and Cell Biology, Nobels Vag 16, Karolinska Institutet
Sweden
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jgid.jgid_79_17

Rights and Permissions

Background: Deformities and neuropathic chronic ulcers are the common features associated with leprosy-cured individuals that impact their quality of life and impair rehabilitation efforts. The challenging aspects for treatment of chronic wounds are the factors that inhibit healing. We reasoned that limited success of various therapeutic interventions could be due to the fact that leprosy-cured individual's physiology gets acclimatized to having a chronic wound that any therapeutic intervention is counterbalanced to maintain status quo at the wound site. Therefore, an alternative strategy would be to use biomaterials that gradually alter the wound site allowing the individual's physiology to participate in the healing process. Aims: Developing the human amnion (Amn)-derived biomaterial scaffolds and evaluating its use to heal chronic wounds in leprosy-cured but deformed persons (LCDPs). Materials and Methods: Using an enzymatic protocol, we have developed a rapid method to generate biomaterial scaffolds from discarded human Amn. A clinical trial on 26 LCDPs was performed with the biomaterial, and its wound-healing potential was then compared with LCDPs undergoing standard treatment procedure. Results: Biomaterial-based treatment of chronic wounds on LCDP displayed a higher efficiency in healing when compared to standard treatment. Conclusions: This study exemplifies that biomaterial-based treatment of leprosy-wounds offers an excellent affordable alternative for wound management. This study underlines the importance of involving both local wound environment and systemic effects for healing. In addition, we highlight wound healing as a necessity for successful rehabilitation and reintegration of leprosy-cured person into the society.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1590    
    Printed40    
    Emailed0    
    PDF Downloaded8    
    Comments [Add]    

Recommend this journal

 

Sitemap | What's New | Feedback | Copyright and Disclaimer | Contact Us
2008 Journal of Global Infectious Diseases | Published by Wolters Kluwer - Medknow
Online since 10th December, 2008