Journal of Global Infectious DiseasesOfficial Publishing of INDUSEM and OPUS 12 Foundation, Inc. Users online:555  
Print this pageEmail this pageSmall font sizeDefault font sizeIncrease font size     
Home About us Editors Ahead of Print Current Issue Archives Search Instructions Subscribe Advertise Login 
 


 
   Table of Contents     
EXPERT RECOMMENDATIONS  
Year : 2016  |  Volume : 8  |  Issue : 4  |  Page : 129-138
Consensus recommendation for India and Bangladesh for the use of pneumococcal vaccine in mass gatherings with special reference to Hajj pilgrims


1 Apollo Institute of Medical Sciences and Research, Apollo Health City Campus, Hyderabad, Telangana, India
2 Directorate General of Health Services, Mohakhali, Bangladesh, India
3 Care Hospital, Hyderabad, Telangana, India
4 Prince Aly Khan Hospital, Mazagaon, Mumbai, Maharashtra, India
5 Department of Pulmonary Medicine, Deccan College of Medical Sciences, Hyderabad, Telangana, India
6 Department of Microbiology, Central Research Laboratory, Kempegowda Institute of Medical Sciences Hospital, Bengaluru, India
7 Kalsekar Hospital, Thane, Mumbai, Maharashtra, India
8 CDC, Directorate General of Health Services, Dhaka, Bangladesh, India
9 Premier Hospital, Mehdipatnam, Hyderabad, Telangana, India
10 Princess Durru Shehvar Children and General Hospital, Hyderabad, Telangana, India
11 New Life Hospital, Hyderabad, Telangana, India
12 Khadija National Hospital, New Delhi, India
13 Rajiv Gandhi University of Health Sciences, Bengaluru, India
14 Olive Hospital, Hyderabad, Telangana, India
15 Haj Committee of India, Haj House, CST, Mumbai, Maharashtra, India
16 Department of Respiratory Medicine, St. Stephens Hospital, New Delhi, India
17 HAQE Medical Center, New Delhi, India

Click here for correspondence address and email

Date of Web Publication10-Nov-2016
 

   Abstract 

Respiratory tract infections are prevalent among Hajj pilgrims with pneumonia being a leading cause of hospitalization. Streptococcus pneumoniae is a common pathogen isolated from patients with pneumonia and respiratory tract infections during Hajj. There is a significant burden of pneumococcal disease in India, which can be prevented. Guidelines for preventive measures and adult immunization have been published in India, but the implementation of the guidelines is low. Data from Bangladesh are available about significant mortality due to respiratory infections; however, literature regarding guidelines for adult immunization is limited. There is a need for extensive awareness programs across India and Bangladesh. Hence, there was a general consensus about the necessity for a rapid and urgent implementation of measures to prevent respiratory infections in pilgrims traveling to Hajj. About ten countries have developed recommendations for pneumococcal vaccination in Hajj pilgrims: France, the USA, Kuwait, Qatar, Bahrain, the UAE (Dubai Health Authority), Singapore, Malaysia, Egypt, and Indonesia. At any given point whether it is Hajj or Umrah, more than a million people are present in the holy places of Mecca and Madina. Therefore, the preventive measures taken for Hajj apply for Umrah as well. This document puts forward the consensus recommendations by a group of twenty doctors following a closed-door discussion based on the scientific evidence available for India and Bangladesh regarding the prevention of respiratory tract infections in Hajj pilgrims.

Keywords: Hajj, pneumococcal vaccination, pneumonia, prevention

How to cite this article:
Mathai D, Shamsuzzaman AK, Feroz AA, Virani AR, Hasan A, Ravi Kumar K L, Ansari K, Forhad Hossain KA, Marda M, Wahab Zubair M A, Ali MM, Ashraf N, Basha R, Mirza S, Ahmed S, Akhtar S, Ashraf SM, Haque Z. Consensus recommendation for India and Bangladesh for the use of pneumococcal vaccine in mass gatherings with special reference to Hajj pilgrims. J Global Infect Dis 2016;8:129-38

How to cite this URL:
Mathai D, Shamsuzzaman AK, Feroz AA, Virani AR, Hasan A, Ravi Kumar K L, Ansari K, Forhad Hossain KA, Marda M, Wahab Zubair M A, Ali MM, Ashraf N, Basha R, Mirza S, Ahmed S, Akhtar S, Ashraf SM, Haque Z. Consensus recommendation for India and Bangladesh for the use of pneumococcal vaccine in mass gatherings with special reference to Hajj pilgrims. J Global Infect Dis [serial online] 2016 [cited 2019 Sep 17];8:129-38. Available from: http://www.jgid.org/text.asp?2016/8/4/129/193749



   Introduction Top


Around 10% of the world's Muslim population (176 million) reside in India. Annually, 3-5 million of Muslims (including 0.17 million from India) embark on Hajj pilgrimage to Mecca, Saudi Arabia. India has the second largest number of Hajj pilgrims each year, after Indonesia. Seventy percent of the quota is government allotted, and 30% of pilgrims undertake private travel.[1]

Respiratory tract infections are common during Hajj.[2] Of these, pneumonia is the most common cause of hospital admission, accounting for one-third of hospitalizations. In a retrospective review of 567 patients hospitalized with pneumonia in Saudi Arabia, the mean age was 43 years (SD 22 years).[2] Streptococcus pneumoniae is a leading cause of pneumonia in Hajj pilgrims.[2],[3] There is a significant burden of community-acquired pneumonia (CAP) in India.[4] Similarly, S. pneumoniae has been isolated as the most common etiological agent for CAP in Bangladesh.[5] While the disease can be treated, prevention also has its own merits.

Guidelines for preventive measures and adult immunization have been published in India, but the implementation of the guidelines is low.[6],[7] Moreover, there is a need for extensive awareness programs across India, taking in account the size and diversity of the country. While there is limited literature available from Bangladesh regarding guidelines for adult immunization for the prevention of respiratory infections; there is evidence of significant mortality due to respiratory infections in Bangladesh.[8],[9] Given this national situation in India and Bangladesh, there has been a general consensus about the necessity for a rapid implementation of measures to prevent respiratory infections in pilgrims traveling to Hajj.[7],[10] These preventive measures cover general measures and specific measures: Vaccination against flu and pneumococci.

While previously, efforts had been made to increase the awareness and education of preventive measures such as vaccination for Hajj pilgrims, there are still challenges in ensuring the pilgrims complete the vaccination before they embark on their journey to Hajj. This document puts forward the consensus recommendations by a group of doctors following a closed-door discussion based on the scientific evidence available for India and Bangladesh regarding the prevention of respiratory tract infections in Hajj pilgrims [Table 1]. Clinical judgment in relation to individual subjects should be relied on before these recommendations are put into practice.
Table 1: Consensus recommendations from India and Bangladesh: 10 key points


Click here to view



   Background of Hajj and Umrah Top


The World Health Organization (WHO) defines mass gatherings as "events attended by a sufficient number of people that strain the planning and response resources of a community, state, or nation."[11] The Centers for Disease Control and Prevention defines a mass gathering as "more than a specified number of people (which may be as few as 1000 although 25,000 is most commonly used), at a specific location, for a specific purpose, for a defined period of time."[12] The most common health problems at mass gatherings are traumatic injuries, respiratory and cardiac issues, heat-related illness, alcohol or drug effects, and gastrointestinal illnesses.[12]

Hajj is one of the largest annual mass gatherings in the world. All able-bodied adult Muslims, who can afford to do so, are required to do it once in a lifetime. Due to Muslim (lunar-based) calendar, Hajj shifts forward by approximately 10 days each successive year, leading to its coincidence with different seasons every few years. Men, women, and children of all ages attend Hajj.[1] There is enormous diversity in terms of ethnic origin and socioeconomic status.[2] Because of the sheer number and crowding of people, stampedes have been known to occur. And also, there is an opportunity for the spread of respiratory infections. Travel to Mecca and Madina outside of the Hajj season is referred to as Umrah. More than a million people are present in the holy places of Mecca and Madina at any given point of time, be it Hajj or Umrah. Thus, preventive measures taken for Hajj apply for Umrah as well.[2]


   Hajj and Umrah: Destination Map Top


The rituals performed during Hajj are depicted in [Figure 1].[12],[13] The Hajj formally begins on the 8th day of Dhul-Hijjah (Zul-Hijjah) - the 12th month of the Muslim lunar calendar.[12],[13] On this 1st day of the Hajj, the pilgrims walk a few miles to Mina and camp there overnight. It falls on a date about 11 days earlier each year. The pilgrims spend the "Day of Arafah" (9th day of Dhul-Hijjah) in Arafah, an empty plain. They commit the entire day to supplication and devotion. In the evening, they move to Muzdalifa. They camp there overnight and offer various prayers.[12],[13] On the 9th day of Dhul-Hijjah, they return to Mina and throw seven pebbles at a pillar that symbolizes Satan's temptation of Abraham. (The Qur'an describes how Satan tried to persuade Abraham to not ritually murder his son Ishmael, as commanded by God). The pilgrims then sacrifice a sheep, recalling how Abraham sacrificed a sheep that God had provided in place of his son. The meat is distributed to friends, relative, and the poor. Afterward, they return to Mecca and perform a final tawaf and sa'i. They symbolize the completion of the Hajj by cutting their hair.[14]
Figure 1: Hajj destination map

Click here to view



   MASS Gatherings: Implications for Infectious Diseases Top


The massive convergence of people from widely distributed geographical areas presents an opportunity for heavy transmission of pathogens between susceptible individuals. Once the mass gathering ends, the returning infected individuals (including asymptomatic ones) can result in rapid dissemination of pathogens, which is exacerbated by air travel. Thus, pilgrims can be exposed to novel, emerging or re-emerging pathogens. Mass gatherings allow for the intermingling of different pathogens or the subtypes of the same pathogen. As the world's population increases, so will the size of mass gatherings. Limiting the effect of infectious disease at mass gatherings will require drawing upon past experiences[15] and strict infection control measures should become the cornerstone for limiting the spread of infectious disease.


   Implications on Morbidity and Mortality of Respiratory Tract Infections during Hajj Top


Lower respiratory tract infection is the most common source of infection leading to severe sepsis and septic shock (>50% of patients).[3] Respiratory diseases are the most common cause of hospital admission during Hajj[16],[17] the Middle East respiratory syndrome (MERS) has a mortality rate exceeding 50%[18] The etiology of respiratory infections during Hajj include: Viral (rhino, influenza, RSV, adeno, hMPV, enterovirus, and corona [MERS-CoV]),[3],[13],[19] bacterial (Pneumococci, Haemophilus influenzae, Mycobacterium tuberculosis, Bordetella pertussis, Streptococci, Chlamydia, Mycoplasma, Legionella, Klebsiella, Pseudomonas, Staphylococcus aureus, and Gram-negative bacteria),[3],[13],[18] and other causes ( Candida).


   Health and Safety Risks during Hajj Top


Besides respiratory tract infections, trauma (e.g., stampede, motor vehicle accidents), heat stroke and heat exhaustion, sunburn, dehydration, and fire-related injuries are known to cause health and safety risks during Hajj . Less common infections causing hospitalization during Hajj include gastroenteritis, skin infection, and sepsis.[20] Infectious diseases presenting a health risk to the pilgrims and local population at all stages of the Hajj include influenza viruses, coronaviruses, pneumococcal sepsis, tuberculosis, meningococcal sepsis, polio, yellow fever, gastrointestinal infections, acute gastroenteritis (e.g.,  Salmonella More Details species, campylobacter species), food poisoning (e.g., bacillus cereus), cholera, typhoid, and dysentery, viral diarrhea (e.g., rotavirus and norovirus), viral hepatitis B, C, D, and E, arboviral infections (e.g., hemorrhagic fevers and Alkhurma virus), parasitic (e.g., malaria, scabies, gut parasites, nematodes, trematodes, and cestodes), fungal (e.g., tinea species skin infections), and blood-borne diseases; human immunodeficiency virus, zoonoses,  Brucellosis More Details, and leishmaniasis.[19]

This part of the document summarizes the general measures and the immunization measures to be undertaken for pilgrims traveling to Hajj and Umrah.


   General Measures Top


General measures related to host defenses; the following[21] are recommended to curb the spread of respiratory infections:

  • Practice frequent hand washing with soap and water or with antiseptic substances (especially after coughing or sneezing)
  • Use napkins while coughing or sneezing and dispose used napkins into waste baskets
  • Try to avoid touching eyes, nose, and mouth
  • Avoid direct contact with symptomatic individuals and do not share belongings with them
  • Wear masks, especially in crowded places
  • Maintain personal cleanliness
  • Stay away from camels and avoid direct contact with them
  • Do not consume raw camel milk or camel meat which is not cooked well
  • Practice smoking cessation; avoid alcohol and unnecessary drug consumption
  • Ensure control of chronic illnesses (diabetes mellitus, chronic obstructive lung disease [COPD], congestive heart failure, chronic renal failure, chronic liver disease, HIV/AIDS infection, etc.,) by visiting health-care provider before embarking for Hajj
  • Take healthy meals on a timely basis and adequate intake of water.



   Measures for Immunization Top


Current recommendations for Hajj and Umrah by the Kingdom of Saudi Arabia

For Hajj, the Kingdom of Saudi Arabia (KSA) requires three mandatory vaccines (meningococcal, poliomyelitis, and yellow fever). The quadrivalent meningococcal vaccine is mandatory for all pilgrims, while polio and yellow fever are for those from endemic areas only. The Saudi Ministry of Health is currently assessing the role of vaccines for the prevention of pneumococcal infections. The ministry is in the process of defining the exact burden of pneumococcal sepsis (pneumonia, meningitis, or invasive disease) during Hajj. It is recommended that pilgrims be up-to-date with the immunization schedule in their home country.[22],[23],[24],[25],[26]

Each country needs to develop its local vaccine recommendation strategy (including flu and pneumococcal vaccine recommendations), regardless of the decisions of KSA or mass gathering center of medicine, which rely (in addition to scientific evidence) on other recommendations by WHO and on local Saudi consensus (including political endorsement).

Influenza vaccination - seasonal flu vaccination can be considered depending on the current season.

Pneumococcal vaccination - around ten countries are engaged in developing or have developed recommendations for pneumococcal vaccination for Hajj pilgrims: France, the USA, Kuwait, Qatar, Bahrain, the UAE (Dubai Health Authority, Health Authority of Abu Dhabi), Singapore, Malaysia, Egypt, and Indonesia. However, there is a lack of consensus as to whether pneumococcal vaccination should be recommended specifically for travelers to Hajj or for all adults. In most countries, the uptake is low.

Health professionals and other professionals involved in front-line health care are a priority group for vaccination because of the increased risk of contracting the illness and transmitting it to their families and their patients. Comprehensive counseling about vaccination by health-care professionals represents one of the principal success factors in achieving vaccination targets.


   Pneumococcal Vaccination Top


Global epidemiology of pneumococcal disease in adults and Hajj pilgrims

S. pneumoniae is the most commonly identified causative pathogen in CAP in adults in most regions of the world. The burden of pneumococcal disease in adults is high, with increasing age and presence of comorbidities having a significant impact on the risk of developing disease. The risk factors for the pneumococcal disease include smoking, age ≥50 years, asthma, diabetes, chronic obstructive lung disease (COPD), alcohol use, HIV, and other immunosuppressive conditions. Age is one of the key risk factors for pneumococcal disease. Comorbidities increase the risk of incidence and morbidity of pneumococcal disease.[7],[11],[27],[28] A recent study showed that the maximum number of pilgrims from India are elderly.[29]


   Impact of Hajj on Pneumococcal Transmission Top


Hajj attendance increases the risk of respiratory infections including pneumonia. S. pneumoniae is a frequently identified pathogen, found in about 10% of respiratory tract samples of symptomatic Hajj pilgrims; and at least 20% of these isolates are penicillin resistant.[28] However, the burden of pneumococcal disease at Hajj is not precisely defined at the serotypic level and it is hypothesized that due to intense mixing of pilgrims, the distribution of pneumococcal serotypes at Hajj could be different from that met with in the pilgrims' country of origin.

As at least one-third of Hajj pilgrims are considered "at risk" of pneumococcal disease either by virtue of age or preexisting medical conditions. Thus, consideration should be given to vaccinating these high-risk pilgrims against pneumococcal disease. Other preventive measures such as smoking cessation, pollution reduction, and vaccinations against influenza and pertussis should also be considered. Precisely defining the epidemiology of pneumococcal disease to identify an optimum vaccination schedule for Hajj pilgrims is a current research priority.

In Saudi Arabia, the most prevalent pneumococcal serotypes are 23F, 6B, 19F, 18C, 4, 14, and 19A, and 90% of the serotypes are covered by pneumococcal vaccination.[27] In the cross-sectional study in Hajj, serotype 3 was the most common serotype in Hajj, followed by 19F and 34.[28] However, due to lack of Hajj-specific data, the Saudi Arabian Ministry of Health has not yet recommended pneumococcal vaccine for pilgrims.


   Pneumococcal Infections at Hajj: Research Trends Top


In a cross-sectional study performed in the KSA during the 2011-2012 Hajj seasons, nasopharyngeal swabs were taken from 3203 Hajj pilgrims (beginning of Hajj: 1,590; end of Hajj: 1,613) from 18 countries. The overall carriage of S. pneumoniae was 6.0%, with the carriage at the beginning and end of Hajj being 4.4% and 7.5%, respectively. Isolates nonsusceptible (at the beginning and end of Hajj) to one antibiotic were 2.5% and 6.1%, respectively, and those nonsusceptible to three or more antibiotics were 0.6% and 2.2%, respectively. A total of 51 serotypes were isolated, with serotype 3 being the most common.[29]

A study on French pilgrims during the 2012 Hajj (n = 169), nasal swabs were taken before departing from France and before departing from the KSA; additional swabs were taken from pilgrims who suffered a respiratory infection during the pilgrimage (41.4%). Before departing from France, 7.3% were positive for S. pneumoniae, while at the end of Hajj, 19.5% tested were positive. Of the 34 pilgrims testing positive for S. pneumoniae during their stay in the KSA, 32 (94.1%) had tested negative before departing from France.[30]

During the 2013 Hajj, nasal and throat swab specimens were obtained from 129 pilgrims before they departed from France and before they left the KSA: Polymerase chain reaction testing of the samples was undertaken for respiratory pathogens. The proportion of specimens positive for S. pneumoniae pre-Hajj was 50.0% and post-Hajj was 62.0%. Of the eighty pilgrims testing positive for S. pneumoniae before leaving the KSA, 29 (36.3%) had tested negative before departing from France.[31]


   Pneumococcal Vaccines Currently Available in India and Bangladesh Top


Currently, two pneumococcal vaccines are available - pneumococcal conjugate vaccine 13 (PCV13) and pneumococcal polysaccharide vaccine 23 (PPV23). PCV13 is a conjugate vaccine while PPV23 is a polysaccharide vaccine. The PCV differs from the PPV in several ways [Table 2]. The PCV13 is effective in infants[32] and has also recently been approved for adults. It induces immunological memory,[32] offers prolonged protection,[32],[33] has a booster effect,[33] does not induce hyporesponsiveness,[32] is known to reduce nasopharyngeal carriage,[34] and offers herd protection.[34] On the other hand, there is demonstrated efficacy of PPV23 against invasive pneumococcal disease (IPD) in adults, but inconsistent data regarding its effectiveness against CAP.[35],[36] In two large meta-analyses performed by Huss et al. and Moberley et al. in the year 2009 and 2008, respectively, when the randomized control trials were taken into account there was little evidence for vaccine protection.[35],[37] Besides, the phenomenon of hyporesponsiveness is seen with revaccination PPV23.[37],[38] PPV23 and PCV13 act differently. This could be an important consideration while making a recommendation for pneumococcal vaccination for Hajj pilgrims, particularly since some pilgrims travel to Hajj more than once in their lifetime. Another important consideration when making a pneumococcal vaccination recommendation is the fact that PCV13 can be safely coadministered with the influenza vaccine in a patient, though at a different site.[39] PCV13 is currently approved in India for children <5 years of age and adults >50 years of age; in contrast, in Bangladesh, PCV13 is approved for all age groups.
Table 2: Table of differences between 13-valent pneumococcal conjugate vaccine and pneumococcal polysaccharide vaccine 23


Click here to view



   Review of Pneumococcal Vaccination Strategies for Adults Top


Advisory Committee on Immunization Practices recommendations for 13-valent pneumococcal conjugate vaccine

In August 2014, the Advisory Committee on Immunization Practice (ACIP) voted to recommend PCV13 for routine use to help protect adults aged 65 years and older against pneumococcal disease caused by the 13 type-specific serotypes included in the vaccine[40] [Table 3].
Table 3: New Advisory Committee on Immunization Practices recommendations for the use of 13-valent pneumococcal conjugate vaccine and pneumococcal polysaccharide vaccine 23


Click here to view


Specifically, the ACIP voted to recommend the following:

  • Adults of 65 years of age or older who have not previously received pneumococcal vaccine or whose previous vaccination history is unknown should receive a dose of PCV13 first, followed by a dose of PPSV23 at least a month later
  • Adults of 65 years of age or older who have not previously received PCV13 and who have previously received one or more doses of PPSV23 should receive a single dose of PCV13.


On December 30, 2011, the US-FDA approved PCV13 for prevention of pneumonia and IPD caused by PCV13 serotypes among adults aged 50 years and older. The US-FDA approved PCV13 for an adult indication under the accelerated approval pathway, which allows the agency to approve products for serious or life-threatening diseases. Approval of PCV13 for adults was based on immunogenicity studies that compared antibody responses to PCV13 with antibody responses to PPV23, a vaccine that is considered to provide protection against IPD but for which no consensus exists regarding protection against nonbacteremic pneumococcal pneumonia.[40] The ACIP recommended PCV13 for routine use in healthy adults based on the following evidence. Pneumococcal pneumonia is the most common type of community-acquired bacterial pneumonia in the US. About 900,000 Americans get pneumococcal pneumonia each year, nearly half of whom require hospitalization.[41] Among adults of 50 years of age and older, there are approximately 440,000 cases of pneumococcal pneumonia each year in the US,[42] with approximately 25,000 pneumococcal disease-related deaths annually[42] Estimates have placed the yearly direct and indirect costs of adult hospitalizations and outpatient cases due to pneumococcal pneumonia in the US at nearly $5 billion.[43]

In addition to this, the ACIP decision was also based on the positive results of the largest to date efficacy trial (community-acquired pneumonia immunization trial in adults [CAPiTA], CAP immunization trial) on PCV13.[44] In this study, 84,496 subjects were vaccinated in a 1:1 ratio with a single dose of PCV13 or placebo.

Recently, the ACIP recommendation was amended for spacing between PCV13 and PPV23 in adults >65 years [Figure 2]. The old ACIP recommended that PPV23 can be given after 6-12 months after PCV13. The new recommendation states that the recommended interval for adults receiving PCV13 and PPV23 to be at least 1 year apart, regardless of sequence.
Figure 2: Chart of vaccination sequence as per ACIP

Click here to view


In summary, this means that PCV13 is given first followed by PPV23 with spacing at least 1 year. If the adult above 65 years received PPV23, then he will receive PCV13 after 1 year as the older recommendation. The ACIP Committee believe that this amendment will have a dual impact; first it will give a better immune response, and second will allow medicare and insurance companies to cover both vaccines since they would not be received in the same year and the spacing now is 1 year, whether started by PCV13 or by PPV23.

There were no clinical studies evaluating the efficacy of the two vaccines given in series available, resulting in the ACIP referencing immunogenicity studies. Data from 16 of these studies suggested that shorter intervals could be associated with greater local reactogenicity; longer intervals could lead to a superior immune response than a single dose of either vaccine. Other considerations included an increased risk window for infection, timing and reducing visits to vaccination providers and revised regulations that cover two pneumococcal vaccines given in series and administered 1-year apart.

Recommended intervals between PCV13 and PPSV23 delivery remain unchanged for persons aged 2 years or older with medical indications, and PPV23 is to be given 8 weeks or more after PCV13 for those aged 19 years or older with certain underlying medical conditions.[45]


   Community-Acquired Pneumonia Immunization Trial in Adults Top


CAPiTA was a randomized, double-blind, placebo-controlled clinical trial of PCV13 versus placebo conducted in the Netherlands in 84,496 subjects aged 65 years or older. The primary outcome was to confirm the efficacy of PCV13 in preventing the first episode of confirmed vaccine-serotype (VT) pneumococcal CAP. The results from CAPiTA have been published in the New England Journal of Medicine [Table 4].[44]
Table 4: Community-Acquired Pneumonia Immunization Trial results


Click here to view


Primary efficacy endpoint

There were 139 first episodes of VT-CAP, which occurred in 49 subjects in the PCV13 group and ninety subjects in the placebo group (vaccine efficacy [VE] were 45.6%; 95.2% confidence interval [CI] 21.8-62.5).

Secondary efficacy endpoints

Nonbacteremia and noninvasive CAP occurred in 33 subjects in the PCV13 group and sixty subjects in the placebo group (VE 45.0%; 95.2% CI, 14.2-65.3); VT-IPD occurred in seven subjects in the PCV13 group and 28 subjects in the placebo group (VE 75.0%; 95% CI, 41.4-90.8). The efficacy persisted throughout the duration of the trial, which had a mean follow-up of 3.97 years. The safety profile of PCV13 in this study was consistent with that observed in previous studies of PCV13 in adults.


   Use of Pneumococcal Vaccination during Hajj Top


The WHO and other regulatory bodies from several countries have identified an unmet medical need for an effective vaccine to prevent pneumococcal pneumonia in adults.[35] Ten countries have developed recommendations for pneumococcal vaccination in Hajj pilgrims; however, the implementation of recommendations is poor. A recent study pointed out that about two-third of the pilgrims have at least one risk factor warranting pneumococcal vaccination; pneumococcal vaccination is indicated for about one-third regardless of the Hajj status; only 7% of pilgrims in whom pneumococcal vaccine was indicated were advised the same by general practitioners, and the overall knowledge of the pilgrims about the severity of pneumonia and the existence of vaccine was low.[46]

The working group for the prevention of pneumococcal disease in Hajj pilgrims recommends that after taking into account the economic situation of the patient, PCV13 may be recommended 4 weeks before travel to Hajj in order to ensure optimal protection against both IPD and pneumonia. PPV23 may be offered to these patients on return from their Hajj journey depending on their risk status. The vaccination sequence to be followed has been mentioned in [Figure 2]. This is in concurrence with the Indian recommendations for vaccination in older adults released by the Geriatric Society of India.[7]

There is a substantial economic burden involved with travel to Hajj. Hajj travel packages typically include airfare, accommodation, meals, and internal bus trips.[47] On an average, the cost is the US $6000 for an individual to make the annual pilgrimage.[48] Cheap packages of around the US $2000 exist but require pilgrims to stay in same-sex dormitories with strangers.[49] Other costs include telephone calls/postage; laundry; food, snacks and drinks, souvenirs, gifts, etc., To this, may be added healthcare-related costs of hospitalization, medications (cost of antibiotic use) and clinical emergencies. Hence, it is important that the most cost-effective and efficacious vaccine for the prevention of pneumonia should be recommended.[50]


   Conclusion Top


Respiratory infections during Hajj can result in an international health emergency situation or an epidemic outbreak. The Saudi Health Ministry requests the concerned countries to raise awareness among the pilgrims about contagious diseases, their symptoms, their modes of spread, complications, and preventive measures. Measures that prevent the spread of infections into Mecca and Madina ultimately prevent the pilgrims carrying infections back to their home countries. This document envisages itself as one such step contributing to the prevention of respiratory infections in Hajj pilgrims from India and Bangladesh.

Acknowledgment
"The Working Group for the prevention of pneumococcal disease in Hajj pilgrims" acknowledges Pfizer limited, India for providing financial support toward conduction a closed-door meeting on the 1st and 2nd August 2015 at Hyderabad for discussion and deliberations on the topic of "Consensus recommendation for India and Bangladesh for the use of pneumococcal vaccine in mass gatherings with special reference to Hajj pilgrims."

Financial support and sponsorship
"The Working Group for the prevention of pneumococcal disease in Hajj pilgrims" had a close-door meeting on the 1st and 2nd August 2015 for discussion and deliberations on the topic of "Consensus recommendation for India and Bangladesh for the use of pneumococcal vaccine in mass gatherings with special reference to Hajj pilgrims" and this meeting was sponsored by Pfizer Limited, India.

Conflicts of interest

There are no conflicts of interest.

 
   References Top

1.
Available from: http://www.hajcommittee.gov.in/. [Last accessed on 2015 Aug 10].  Back to cited text no. 1
    
2.
Feldman C, Abdulkarim E, Alattar F, Al Lawati F, Al Khatib H, Al Maslamani M, et al. Pneumococcal disease in the Arabian Gulf: Recognizing the challenge and moving toward a solution. J Infect Public Health 2013;6:401-9.  Back to cited text no. 2
    
3.
Baharoon S, Al-Jahdali H, Al Hashmi J, Memish ZA, Ahmed QA. Severe sepsis and septic shock at the Hajj: Etiologies and outcomes. Travel Med Infect Dis 2009;7:247-52.  Back to cited text no. 3
    
4.
Fedson DS, Scott JA. The burden of pneumococcal disease among adults in developed and developing countries: What is and is not known. Vaccine 1999 30;17 Suppl 1:S11-8.  Back to cited text no. 4
    
5.
Akter S, Shamsuzzaman SM, Jahan F. Community acquired bacterial pneumonia: Aetiology, laboratory detection and antibiotic susceptibility pattern. Malays J Pathol 2014;36:97-103.  Back to cited text no. 5
    
6.
Senthur Nambi P, Ramasubramaniam V. Vaccines for travelers, immigrants and migrants: Indian Guidelines. In: Muruganathan A, Mathai D, Sharma SK, editors. Adult Immunization 2014. API Guidelines. 2014. (31) 225-36. Published by The Association of Physicians of India.  Back to cited text no. 6
    
7.
Sharma OP, editor. Indian Recommendations for Vaccination in Older Adult - A Guide for Geriatricians, Internists, Chest Physicians, Surgeons, Family Physicians Developed by Geriatric Society of India. 2015. Published by Geriatric Society of India.  Back to cited text no. 7
    
8.
Alam N, Chowdhury HR, Das SC, Ashraf A, Streatfield PK. Causes of death in two rural demographic surveillance sites in Bangladesh, 2004-2010: Automated coding of verbal autopsies using InterVA-4. Glob Health Action 2014;7:25511.  Back to cited text no. 8
    
9.
Hanifi SM, Mahmood SS, Bhuiya A. Cause-specific mortality and socioeconomic status in Chakaria, Bangladesh. Glob Health Action 2014;7:25473.  Back to cited text no. 9
    
10.
Swaminathan S, Balajee G. Pneumococcal Vaccines - A real world perspective. J Assoc Physicians India 2015;63 4 Suppl: 25-8.  Back to cited text no. 10
    
11.
World Health Organization. Communicable Disease Alert and Response for Mass Gatherings: Key Considerations. Geneva: World Health Organization; 2008. Available from: http://www.who.int/csr/Mass_gatherings2.pdf. [Last accessed on 2015 Aug 14].  Back to cited text no. 11
    
12.
Centers for Disease Control and Prevention. CDC Health Information for International Travel 2014. New York: Oxford University Press; 2014.  Back to cited text no. 12
    
13.
Bowron SC, Maalim SM. Saudi Arabia: Hajj Pilgrimage. Available from: http://www.nc.cdc.gov/travel/yellowbook/2016/select-destinations/saudi-arabia-hajj-pilgrimage. [Last accessed on 2015 Aug 26].  Back to cited text no. 13
    
14.
Available from: http://www.religioustolerance.org/isla1.htm. [Last accessed on 2015 Oct 18].  Back to cited text no. 14
    
15.
Kok J, Blyth CC, Dwyer DE. Mass gatherings and the implications for the spread of infectious diseases. Future Microbiol 2012;7:551-3.  Back to cited text no. 15
    
16.
Abubakar I, Gautret P, Brunette GW, Blumberg L, Johnson D, Poumerol G, et al. Global perspectives for prevention of infectious diseases associated with mass gatherings. Lancet Infect Dis 2012;12:66-74.  Back to cited text no. 16
    
17.
Al-Ghamdi SM, Akbar HO, Qari YA, Fathaldin OA, Al-Rashed RS. Pattern of admission to hospitals during Muslim pilgrimage (Hajj). Saudi Med J 2003;24:1073-6.  Back to cited text no. 17
    
18.
Khan K, Sears J, Hu VW, Brownstein JS, Hay S, Kossowsky D, et al. Potential for the international spread of middle East respiratory syndrome in association with mass gatherings in saudi arabia. PLoS currents. 2013.17;5.  Back to cited text no. 18
    
19.
Al-Tawfiq JA, Memish ZA. The Hajj: Updated health hazards and current recommendations for 2012. Euro Surveill 2012;17:20295.  Back to cited text no. 19
    
20.
Memish ZA. The Hajj: Communicable and non-communicable health hazards and current guidance for pilgrims. Euro Surveill 2010;15:19671.  Back to cited text no. 20
    
21.
Froes F, Diniz A, Robalo Cordeiro C, Serrado M, Ramalho de Almeida A; Portuguese Respiratory Society. Consensus document for the prevention of respiratory infections in adults. Rev Port Pneumol 2014;20:111-4.  Back to cited text no. 21
    
22.
Memish ZA, Assiri AM, Hussain R, Alomar I, Stephens G. Detection of respiratory viruses among pilgrims in Saudi Arabia during the time of a declared influenza A (H1N1) pandemic. J Travel Med 2012;19:15-21.  Back to cited text no. 22
    
23.
Available from: http://www.moh.gov.sa/en/Hajj/HealthGuidelines/Pages/BeforeHajj.aspx; [Last accessed on 2015 Aug 14].  Back to cited text no. 23
    
24.
Available from: http://www.saudiembassy.net/services/Hajj_requirements.aspx. [Last accessed on 2015 Aug 14].  Back to cited text no. 24
    
25.
World Health Organization. "Rubella Virus Nomenclature Update. Wkly Epidemiol Rec 2013;88 (32):337-48.  Back to cited text no. 25
    
26.
Memish ZA, Zumla A, Alhakeem RF, Assiri A, Turkestani A, Al Harby KD, et al. Hajj: Infectious disease surveillance and control. Lancet 2014;383:2073-82.  Back to cited text no. 26
    
27.
Sanz Herrero F, Blanquer Olivas J. Microbiology and risk factors for community-acquired pneumonia. Semin Respir Crit Care Med 2012;33:220-31.  Back to cited text no. 27
    
28.
Ridda I, King C, Rashid H. Pneumococcal infections at Hajj: Current knowledge gaps. Infect Disord Drug Targets 2014;14:177-84.  Back to cited text no. 28
    
29.
Memish ZA, Assiri A, Turkestani A, Yezli S, Al Masri M, Charrel R, et al. Mass gathering and globalization of respiratory pathogens during the 2013 Hajj. Clin Microbiol Infect 2015;21:571.e1-8.  Back to cited text no. 29
    
30.
Benkouiten S, Charrel R, Belhouchat K, Drali T, Salez N, Nougairede A, et al. Circulation of respiratory viruses among pilgrims during the 2012 Hajj pilgrimage. Clin Infect Dis 2013;57:992-1000.  Back to cited text no. 30
    
31.
Benkouiten S, Charrel R, Belhouchat K, Drali T, Nougairede A, Salez N, et al. Respiratory viruses and bacteria among pilgrims during the 2013 Hajj. Emerg Infect Dis 2014;20:1821-7.  Back to cited text no. 31
    
32.
Blanchard-Rohner G, Pollard AJ. Long-term protection after immunization with protein-polysaccharide conjugate vaccines in infancy. Expert Rev Vaccines 2011;10:673-84.  Back to cited text no. 32
    
33.
Pollard AJ, Perrett KP, Beverley PC. Maintaining protection against invasive bacteria with protein-polysaccharide conjugate vaccines. Nat Rev Immunol 2009;9:213-20.  Back to cited text no. 33
    
34.
Mäkelä PH, Käyhty H. Evolution of conjugate vaccines. Expert Rev Vaccines 2002;1:399-410.  Back to cited text no. 34
    
35.
Huss A, Scott P, Stuck AE, Trotter C, Egger M. Efficacy of pneumococcal vaccination in adults: A meta-analysis. CMAJ 2009;180:48-58.  Back to cited text no. 35
    
36.
Leventer-Roberts M, Feldman BS, Brufman I, Cohen-Stavi CJ, Hoshen M, Balicer RD. Effectiveness of 23-valent pneumococcal polysaccharide vaccine against invasive disease and hospital-treated pneumonia among people aged ≥65 years: A retrospective case-control study. Clin Infect Dis 2015;60:1472-80.  Back to cited text no. 36
    
37.
Moberley SA, Holden J, Tatham DP, Andrews RM. Vaccines for preventing pneumococcal infection in adults. Cochrane Database Syst Rev 2008; (1).CD000422.  Back to cited text no. 37
    
38.
Clutterbuck EA, Lazarus R, Yu LM, Bowman J, Bateman EA, Diggle L, et al. Pneumococcal conjugate and plain polysaccharide vaccines have divergent effects on antigen-specific B cells. J Infect Dis 2012;205:1408-16.  Back to cited text no. 38
    
39.
Schwarz TF, Flamaing J, Rümke HC, Penzes J, Juergens C, Wenz A, et al. A randomized, double-blind trial to evaluate immunogenicity and safety of 13-valent pneumococcal conjugate vaccine given concomitantly with trivalent influenza vaccine in adults aged≥65 years. Vaccine 2011 18;29:5195-202.  Back to cited text no. 39
    
40.
Tomczyk S, Bennett NM, Stoecker C, Gierke R, Moore MR, Whitney CG, et al. Use of 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine among adults aged ≥65 years: Recommendations of the advisory committee on immunization practices (ACIP). MMWR Morb Mortal Wkly Rep 2014;63 Suppl 37:822-5.  Back to cited text no. 40
    
41.
Centers for Disease Control and Prevention. Pneumococcal Disease - Fast Facts. Available from: http://www.cdc.gov/pneumococcal/about/facts.html. [Last accessed on 2014 Mar 12].  Back to cited text no. 41
    
42.
Huang SS, Johnson KM, Ray GT, Wroe P, Lieu TA, Moore MR, et al. Healthcare utilization and cost of pneumococcal disease in the United States. Vaccine 2011;29:3398-412.  Back to cited text no. 42
    
43.
Weycker D, Strutton D, Edelsberg J, Sato R, Jackson LA. Clinical and economic burden of pneumococcal disease in older US adults. Vaccine 2010;28:4955-60.  Back to cited text no. 43
    
44.
Bonten MJ, Huijts SM, Bolkenbaas M, Webber C, Patterson S, Gault S, et al. Polysaccharide conjugate vaccine against pneumococcal pneumonia in adults. N Engl J Med 2015;372:1114-25.  Back to cited text no. 44
    
45.
Available from: http://www.cdc.gov/vaccines/vpd-vac/pneumo/vac-PCV13-adults.htm. [Last accessed on 2015 Sep 11].  Back to cited text no. 45
    
46.
Sridhar S, Belhouchat K, Drali T, Benkouiten S, Parola P, Brouqui P, et al. French Hajj pilgrims′ experience with pneumococcal infection and vaccination: A knowledge, attitudes and practice (KAP) evaluation. Travel Med Infect Dis 2015;13:251-5.  Back to cited text no. 46
    
47.
Available from: http://www.hajtips.com/expenses.htm.[ Last accessed on 2015 Aug 14].  Back to cited text no. 47
    
48.
Available from: http://www.arabiangazette.com/economics-hajj-20130530/. [Last accessed on 2015 Aug 14].  Back to cited text no. 48
    
49.
Available from: http://www.factsanddetails.com/world.php?itemid=1443 and. [Last accessed on 2015 Aug 14].  Back to cited text no. 49
    
50.
Plosker GL 13-Valent Pneumococcal Conjugate Vaccine: A Review of Its Use in Adults. Drugs 2015;75:1535-46.  Back to cited text no. 50
    

Top
Correspondence Address:
Dr. Dilip Mathai
Apollo Institute of Medical Sciences and Research, Apollo Health City Campus, Hyderabad, Telangana
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-777X.193749

Rights and Permissions


    Figures

  [Figure 1], [Figure 2]
 
 
    Tables

  [Table 1], [Table 2], [Table 3], [Table 4]



 

Top
  
 
  Search
 
  
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Email Alert *
    Add to My List *
* Registration required (free)  


    Abstract
   Introduction
    Background of Ha...
    Hajj and Umrah: ...
    MASS Gatherings:...
    Health and Safet...
   General Measures
    Measures for Imm...
    Pneumococcal Vac...
    Impact of Hajj o...
    Pneumococcal Inf...
    Pneumococcal Vac...
    Review of Pneumo...
    Community-Acquir...
    Use of Pneumococ...
   Conclusion
    Implications on ...
    References
    Article Figures
    Article Tables

 Article Access Statistics
    Viewed2421    
    Printed24    
    Emailed0    
    PDF Downloaded22    
    Comments [Add]    

Recommend this journal

Sitemap | What's New | Feedback | Copyright and Disclaimer | Contact Us
2008 Journal of Global Infectious Diseases | Published by Wolters Kluwer - Medknow
Online since 10th December, 2008