Journal of Global Infectious DiseasesOfficial Publishing of INDUSEM and OPUS 12 Foundation, Inc. Users online:1027  
Print this pageEmail this pageSmall font sizeDefault font sizeIncrease font size     
Home About us Editors Ahead of Print Current Issue Archives Search Instructions Subscribe Advertise Login 
 
ORIGINAL ARTICLE
Year : 2016  |  Volume : 8  |  Issue : 3  |  Page : 108-114

Phylogenetic analysis of human immunodeficiency virus type 2 group B


1 Department of Infectious, Parasitic and Immunomediated Diseases, National Institute of Health, Rome; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy
2 Department of Infectious, Parasitic and Immunomediated Diseases, National Institute of Health, Rome, Italy
3 Department of Infectious, Parasitic and Immunomediated Diseases, National Institute of Health, Rome; Department of Biology, General Pathology Laboratory, University of Rome Tor Vergata, Rome, Italy
4 Department of Biomedical and Clinical Sciences L. Sacco, University of Milan, Milan, Italy
5 Clinical Pathology and Microbiology Laboratory, University Hospital Campus Bio-Medico of Rome, Rome, Italy
6 Laboratory of Molecular Virology, Tor Vergata Foundation Hospital, Rome, Italy
7 Department of Infectious, Parasitic and Immunomediated Diseases, National Institute of Health, Rome; Clinical Pathology and Microbiology Laboratory, University Hospital Campus Bio-Medico, Rome, Italy

Correspondence Address:
Dr. Massimo Ciccozzi
Department of Infectious, Parasitic and Immunomediated Diseases, National Institute of Health, Rome; Clinical Pathology and Microbiology Laboratory, University Hospital Campus Bio-Medico, Rome
Italy
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-777X.188592

Rights and Permissions

Context: Human immunodeficiency virus type 2 (HIV-2) infections are mainly restricted to West Africa; however, in the recent years, the prevalence of HIV-2 is a growing concern in some European countries and the Southwestern region of India. Despite the presence of different HIV-2 groups, only A and B Groups have established human-to-human transmission chains. Aims: This work aimed to evaluate the phylogeographic inference of HIV-2 Group B worldwide to estimate their data of origin and the population dynamics. Materials and Methods: The evolutionary rates, the demographic history for HIV-2 Group B dataset, and the phylogeographic analysis were estimated using a Bayesian approach. The viral gene flow analysis was used to count viral gene out/in flow among different locations. Results: The root of the Bayesian maximum clade credibility tree of HIV-2 Group B dated back to 1957. The demographic history of HIV-2 Group B showed that the epidemic remained constant up to 1970 when started an exponential growth. From 1985 to early 2000s, the epidemic reached a plateau, and then it was characterized by two bottlenecks and a new plateau at the end of 2000s. Phylogeographic reconstruction showed that the most probable location for the root of the tree was Ghana. Regarding the viral gene flow of HIV-2 Group B, the only observed viral gene flow was from Africa to France, Belgium, and Luxembourg. Conclusions: The study gives insights into the origin, history, and phylogeography of HIV-2 Group B epidemic. The growing number of infections of HIV-2 worldwide indicates the need for strengthening surveillance.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2505    
    Printed43    
    Emailed0    
    PDF Downloaded25    
    Comments [Add]    

Recommend this journal

 

Sitemap | What's New | Feedback | Copyright and Disclaimer | Contact Us
2008 Journal of Global Infectious Diseases | Published by Wolters Kluwer - Medknow
Online since 10th December, 2008