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   Table of Contents     
LETTER TO EDITOR  
Year : 2014  |  Volume : 6  |  Issue : 4  |  Page : 196-197
The HIV associated type 2 diabetes


1 Department of Community Medicine, Sri Muthukumaran Medical College and Research Institue, Mangadu, Chennai, Tamil Nadu, India
2 Department of Microbiology, Sri Muthukumaran Medical College and Research Institue, Mangadu, Chennai, Tamil Nadu, India
3 Department of Microbiology, Meenakshi Medical College and Research Institute, Enathur, Kanchipuram, Tamil Nadu, India

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Date of Web Publication21-Nov-2014
 

How to cite this article:
Kasthuri A, Mohanakrishnan K, Amsavathani S K, Sumathi G. The HIV associated type 2 diabetes . J Global Infect Dis 2014;6:196-7

How to cite this URL:
Kasthuri A, Mohanakrishnan K, Amsavathani S K, Sumathi G. The HIV associated type 2 diabetes . J Global Infect Dis [serial online] 2014 [cited 2019 Dec 13];6:196-7. Available from: http://www.jgid.org/text.asp?2014/6/4/196/145262


Sir,

HIV and diabetes are both chronic diseases that significantly affects lifestyle. HIV-associated diabetes refers to type 2 diabetes occurring among individuals with HIV who may not otherwise have traditional risk factors for diabetes. The association between HIV infection and diabetes mellitus is poorly understood and complicated by the differential prevalence of risk factors for diabetes in HIV infected persons compared with HIV uninfected persons. [1],[2],[3]

A study was done mainly concentrating on the rural HIV infected nondiabetic population at the diagnostic stage and the risk of getting type 2 diabetes during follow-up. This study mainly focused on patients who were newly diagnosed for HIV infection, nondiabetic, unexposed to anti-retroviral drugs and did not have the direct risk factors for type 2 diabetes like >40 years, obesity, and family history. The 50 eligible HIV reactive patients from 25 to 40 years were included in the group after obtaining the informed consent for the research. At the time of follow-up visit the venous plasma glucose levels were measured during the fasting and postprandial state from the 50 reactive and diabetes risk free anti-retroviral therapy naïve patients. The American diabetes association criteria followed that is, fasting 100-124 mg is impaired fasting glucose, postprandial 140-200 mg is impaired glucose tolerance and fasting >124 mg and postprandial >200 mg is labeled as type 2 diabetes.

The results revealed only one patient with diabetes and one more patient with impaired glucose tolerance. Both were males, married, alcoholics, and smokers. Like all other 50 patients, both were not having any direct risk factors for type 2 diabetes. The person who was diagnosed with impaired glucose tolerance was found to be positive for HbsAg, but negative for HCV. In our present study, the new onset of diabetes during follow-up was only 2%, which was minimal comparing to the CPCRA clinical trials and the NHANES which showed 3.3% and 4.8%. [4] In our study, one patient with HbsAg coinfection found to be present with impaired glucose tolerance. There are very few studies analyzed the HIV and HbsAg coinfection and association of type 2 diabetes.

The outcome of the present study may be insufficient to establish the direct relationship between HIV and type 2 diabetes. The patients reactive for HIV should also be screened for type 2 diabetes, even though the prevalence of type 2 diabetes among HIV patients is less, because, when they intersect, the treatment regimens required for both diseases can be overwhelming for patients. Furthermore, the patients with risk factors must be instructed to follow the lifestyle such as increased physical activity, healthy, well-balanced diet, and food intake, which can prevent the development of type 2 diabetes. Many longitudinal cohort studies involving a large number of patients are needed in India to understand the glucose metabolism alterations in HIV patients with or without highly active anti-retroviral therapy.

 
   References Top

1.
Goulet JL, Fultz SL, McGinnis KA, Justice AC. Relative prevalence of comorbidities and treatment contraindications in HIV-mono-infected and HIV/HCV-co-infected veterans. AIDS 2005;19 Suppl 3:S99-105.  Back to cited text no. 1
    
2.
Goulet JL, Fultz SL, Rimland D, Butt A, Gibert C, Rodriguez-Barradas M, et al. Aging and infectious diseases: Do patterns of comorbidity vary by HIV status, age, and HIV severity? Clin Infect Dis 2007;45:1593-601.  Back to cited text no. 2
    
3.
Kilbourne AM, Justice AC, Rabeneck L, Rodriguez-Barradas M, Weissman S, VACS 3 Project Team. General medical and psychiatric comorbidity among HIV-infected veterans in the post-HAART era. J Clin Epidemiol 2001;54 Suppl 1:S22-8.  Back to cited text no. 3
    
4.
Brar I, Shuter J, Thomas A, Daniels E, Absalon J, Minorities and Women's Task Force of Terry Beirn Community Programs for Clinical Research on AIDS. A comparison of factors associated with prevalent diabetes mellitus among HIV-Infected antiretroviral-naive individuals versus individuals in the National Health and Nutritional Examination Survey cohort. J Acquir Immune Defic Syndr 2007;45:66-71.  Back to cited text no. 4
    

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Correspondence Address:
A Kasthuri
Department of Community Medicine, Sri Muthukumaran Medical College and Research Institue, Mangadu, Chennai, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-777X.145262

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2008 Journal of Global Infectious Diseases | Published by Wolters Kluwer - Medknow
Online since 10th December, 2008