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LETTER TO EDITOR  
Year : 2013  |  Volume : 5  |  Issue : 3  |  Page : 121
Serological evaluation of leptospirosis: A report from western India


Department of Microbiology, Smt. Kashibai Navale Medical College and General Hospital, Survey No. 49/1, 53/2, Off Mumbai-Pune Bypass, Narhe Ambegaon (Bk), Pune, Maharashtra, India

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Date of Web Publication23-Aug-2013
 

How to cite this article:
Ghadage DP, Muley VA, Bhore AV. Serological evaluation of leptospirosis: A report from western India. J Global Infect Dis 2013;5:121

How to cite this URL:
Ghadage DP, Muley VA, Bhore AV. Serological evaluation of leptospirosis: A report from western India. J Global Infect Dis [serial online] 2013 [cited 2019 Aug 21];5:121. Available from: http://www.jgid.org/text.asp?2013/5/3/121/116877


Dear Editor,

Leptospirosis is a zoonotic disease with humans getting the infection either from rodent hosts or from domestic animals. [1],[2] The disease, if not diagnosed and treated at an early stage, can cause fatal complications. Hence, early confirmation of the diagnosis improves the prognosis. [3]

In the present study, serological evaluation of human subjects suspected of leptospirosis was done. Serological tests used were Leptotek Dri-Dot test, IgM ELISA and MAT either in combination or singly.

A total of 882 serum samples were received in the Regional Diagnostic Centre during one year period. Out of 25.1% samples processed by Dri-Dot test, 11.2% were positive by Dri-Dot test. IgM ELISA was performed on 585 (66.3%) samples. 37% of these were positive by IgM ELISA. Fifty samples were tested by both the tests, Dri-Dot and IgM ELISA. 36% samples were positive by both the tests. 16% were positive by Dri-Dot but negative by IgM ELISA. 2% samples were negative by Dr-Dot but positive by IgM ELISA. 25 samples were subjected to MAT, out of which 44% were positive by MAT. Icterohaemorrhagiae was found to be the predominant serovar.

Dri-Dot test is sensitive, rapid and easy to perform. However, it is less specific than IgM ELISA. Hence,

Dri-Dot test can be used at periphery where facility for ELISA is not available. In a hospital scenario, laboratory diagnosis should be done by ELISA.

 
   References Top

1.Tappero JW, Ashford DA, Perkins BA. Leptospira species (leptospirosis). In: Mandell GL, Bennett JE, Dolin R, editors. Principles and practice of infectious diseases. 5 th ed. Philadelphia: Churchill Livingstone; 2000. p. 2495-501.  Back to cited text no. 1
    
2.Velineni S, Asuthkar S, Umabala P, Lakshmi V, Sritharan M. Serological evaluation of leptospirosis in Hyderabad, Andhra Pradesh: A retrospective hospital-based study. Indian J Med Microbiol 2007;25:24-7.   Back to cited text no. 2
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3.Vijayachari P, Sugunan AP, Sehgal SC. Evaluation of Lepto Dri Dot as a rapid test for the diagnosis of leptospirosis. Epidemiol Infect 2002;129:617-21.  Back to cited text no. 3
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Correspondence Address:
Vrishali A Muley
Department of Microbiology, Smt. Kashibai Navale Medical College and General Hospital, Survey No. 49/1, 53/2, Off Mumbai-Pune Bypass, Narhe Ambegaon (Bk), Pune, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-777X.116877

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2008 Journal of Global Infectious Diseases | Published by Wolters Kluwer - Medknow
Online since 10th December, 2008