Journal of Global Infectious DiseasesOfficial Publishing of INDUSEM and OPUS 12 Foundation, Inc. Users online:1213  
Print this pageEmail this pageSmall font sizeDefault font sizeIncrease font size     
Home About us Editors Ahead of Print Current Issue Archives Search Instructions Subscribe Advertise Login 
 


 
   Table of Contents     
LETTER TO EDITOR  
Year : 2013  |  Volume : 5  |  Issue : 2  |  Page : 85-86
Nontuberculous mycobacterial arthritis of the first metatarsophalangeal joint in a young immunocompetent adult: An interesting case report


1 Department of Pathology, MAPIMS, Melmaruvathur, Tamil Nadu, India
2 Department of Orthopedics, M.S. Ramaiah Medical College, Bangalore, Karnataka, India
3 Department of Biochemistry, Sapthagiri Institute of Medical Sciences and Research Center, Bangalore, Karnataka, India

Click here for correspondence address and email

Date of Web Publication20-May-2013
 

How to cite this article:
Vamseedhar A, Padmanabhan AK, Chakkirala NM, Darbur RS. Nontuberculous mycobacterial arthritis of the first metatarsophalangeal joint in a young immunocompetent adult: An interesting case report. J Global Infect Dis 2013;5:85-6

How to cite this URL:
Vamseedhar A, Padmanabhan AK, Chakkirala NM, Darbur RS. Nontuberculous mycobacterial arthritis of the first metatarsophalangeal joint in a young immunocompetent adult: An interesting case report. J Global Infect Dis [serial online] 2013 [cited 2019 Aug 25];5:85-6. Available from: http://www.jgid.org/text.asp?2013/5/2/85/112280


Sir,

Nontuberculous mycobacterial (NTM) infections involve the musculoskeletal system in approximately 5-10% of the patients. [1] The most common manifestation of NTM infections is osteomyelitis. However, swelling and lytic lesions of the affected bone are rarely seen. [2]

A 19-year-old male presented with pain and swelling of the right great toe since three months. No punctured wound was reported. Past history and family history were not contributory. A plain roentgenogram of the right foot revealed [Figure 1] a lytic lesion at the base of the first metatarsal bone, with arthritic changes of the first metatarsophalangeal joint, surrounding soft tissue swelling, and erosion of the base of the first phalanx. The patient was empirically started with a combination of ceftriaxone 1 g/day and netilmicin 150 mg twice/day, administered intravenously for 15 days, and subsequently an oral therapy of ciprofloxacin 250 mg twice/day for one month with regular follow-up. However, the symptoms continued to aggravate and did not show any improvement. His erythrocyte sedimentation rate was 30 mm/hour. The chest roentgenogram was normal. An Enzyme-Linked Immunosorbent Assay test for human immunodeficiency virus (HIV) detection was negative. A surgical incision and drainage procedure was performed. The debrided synovial tissue was submitted for histopathology and microbiology examinations. The microscopic examination revealed multiple well-formed, epithelioid granulomas, without caseous necrosis [Figure 2]. The Ziehl Neelsen stain was negative for acid fast bacilli. The culture for mycobacterium tuberculosis was negative. A tuberculin skin test was negative. The Mycobacterium COMBO test for detection of IgM antibodies against two highly purified antigens, derived from the Mycobacterium, namely, the cell wall and 38kDa antigens, was elevated (1.03 index value). A repeat culture from the lesion was performed, which identified the mycobacterium avium complex (MAC) species. A final diagnosis of NTM arthritis of the right first metatarsophalangeal joint, caused by MAC species, was made based on the correlation of the clinical features, and the radiology, histopathology, and microbiology findings. The patient received a one-year course of Azithromycin 1000 mg/day, Ethambutol 15 mg/kg/day, rifabutin 150 mg/day, along with indomethacin, which resulted in resolution of the lesions in the patient, with follow-up.

Unlike M. tuberculosis, NTM is not transmitted from person to person. [1],[2] Most osseous infections are caused by Mycobacterium kansasii and Mycobacterium scrofulaceum.[3] With NTM infection, the onset of nonspecific symptoms is indolent and usually includes local pain and swelling, joint stiffness, low-grade fever, sweats, chills, anorexia, malaise, and weight loss. The triad of Phemister, consisting of osteoporosis, peripheral marginal erosions, and slowly progressing destruction of the articular cartilage, characterizes mycobacterial arthritis. [4] On account of their infrequent occurrence and difficulty in identification, with a lack of specificity of imaging findings, a heightened clinical suspicion of slow-growing nonchromogenic mycobacterial species in cases of arthritis is needed, when a routine bacterial culture or histopathological findings do not readily identify an organism. [5] The prescribed management in the setting of NTM infection is the combination of different antituberculous drugs and antibiotics, along with surgical drainage, which was administered to our patient, resulting in a favorable outcome.
Figure 1: Lytic lesion (Double arrowhead) at the base of the first metatarsal bone with surrounding soft tissue swelling and erosion of the base of the first phalanx (Single arrowhead)

Click here to view
Figure 2: (H and E, 400): Well-formed epithelioid granulomas with Langhans giant cells and necrosis

Click here to view


 
   References Top

1.Griffith DE, Aksamit T, Brown-Elliott BA, Catanzaro A, Daley C, Gordin F, et al. An official ATS/IDSA statement: Diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med 2007;175:367-416.  Back to cited text no. 1
    
2.Piersimoni C, Scarparo C. Extrapulmonary infections associated with nontuberculous mycobacteria in immunocompetent persons. Emerg Infect Dis 2009;15:1351-8.  Back to cited text no. 2
    
3.Wolinsky E. Mycobacterial diseases other than tuberculosis. Clin Infect Dis 1992;15:1-12.  Back to cited text no. 3
    
4.Marchevsky A, Damsker B, Green S, Tepper S. The clinicopathological spectrum of nontuberculous mycobacterial osteoarticular infections. J Bone Joint Surg Am 1985;67:925-9.  Back to cited text no. 4
    
5.Watterson SA, Drobniewski FA. Modern laboratory diagnosis of mycobacterial infections. J Clin Pathol 2000;53:727-32.  Back to cited text no. 5
    

Top
Correspondence Address:
Annam Vamseedhar
Department of Pathology, MAPIMS, Melmaruvathur, Tamil Nadu
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-777X.112280

Rights and Permissions


    Figures

  [Figure 1], [Figure 2]



 

Top
  
 
  Search
 
  
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Email Alert *
    Add to My List *
* Registration required (free)  


    References
    Article Figures

 Article Access Statistics
    Viewed1099    
    Printed47    
    Emailed2    
    PDF Downloaded9    
    Comments [Add]    

Recommend this journal

Sitemap | What's New | Feedback | Copyright and Disclaimer | Contact Us
2008 Journal of Global Infectious Diseases | Published by Wolters Kluwer - Medknow
Online since 10th December, 2008