| ORIGINAL ARTICLE |
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| Year : 2012 | Volume
: 4
| Issue : 4 | Page : 199-206 |
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Comparison of adenosine deaminase, zinc, magnesium, lipid profile, and some micronutrient elements and their relation with CD4 counts in human immunodeficiency virus positive and negative patients
Alireza Abdollahi1, Saeed Shoar2
1 Department of Pathology, Imam Teaching Hospital, Tehran, Iran
2 Department of Pathology, Imam Teaching Hospital; Development Association for Clinical Studies, Tehran University of Medical Sciences, Tehran, Iran
Correspondence Address:
Alireza Abdollahi
Department of Pathology, Imam Teaching Hospital, Tehran
Iran
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0974-777X.103897
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Background: There is strong evidence regarding the patterns of alteration in the blood parameters in human immunodeficiency
virus (HIV)-positive patients. However, no consensus has been reached in this regard and the results vary from different regions and studies. Our study aims to report these patterns in a population of HIV-infected patients in Iran. Materials and Methods: We studied two groups of HIV-infected and HIV-negative patients. One hundred and fourteen subjects were enrolled in each group; blood parameters were compared in these two. Results: Variables of HIV-negative patients changed as follows compared to HIV-positive patients: with regard to the hematological variables, CD4+↓; CD8+↓; WBC↓; RBC↓; HCT↓ ; MCV↑ ; MCH↑; MCHC↑; PLT↓; EOS↑; and BASO↑; and among the metabloic parameters, TG↓; CH↑; HDL↓; LDL↓, MG↑; ZN↑; P↑; and ADA↓, which showed significnat differences between groups (P < 0.05). Conclusion: We conclude that HIV infection affects hematopoiesis by diminishing the hematological productivity parameters and increasing red blood cell related morphology, along with a different pattern of lipid profile (decreased TG, LDL, HDL, and increased CH) and serum micronutrients (elevated concentration of serum trace elements) in our population of study. |
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