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CASE REPORT
Year : 2012  |  Volume : 4  |  Issue : 2  |  Page : 128-131

Multisystem sarcoidosis in a patient on interferon-α therapy for chronic hepatitis C


1 Department of Hepatogastroenterology, University Hospital of Fez, Morocco
2 Clinical Neurosciences Laboratory, Faculty of Medicine and Pharmacy of Fez; Department of Neurosurgery, University Hospital of Fez, Morocco
3 Clinical Neurosciences Laboratory, Department of Biophysics and Clinical MRI Methods, Faculty of Medicine and Pharmacy of Fez, Morocco
4 Department of Neurosurgery and Neurology, University Hospital of Fez, Morocco

Correspondence Address:
Sad Boujraf
Clinical Neurosciences Laboratory, Department of Biophysics and Clinical MRI Methods, Faculty of Medicine and Pharmacy of Fez
Morocco
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-777X.96779

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Sarcoidosis is a chronic multisystemic granulomatous disease that is triggered by an autoimmune process. Nowadays, this pathology represents a well-recognized but uncommon complication for antiviral treatment in hepatitis C virus (HCV) infection. Herein, we report a remarkable case of 47-year-old woman treated for chronic HCV infection; the patient has developed interferon alfa-induced sarcoidosis involving the central nervous system. The evolution was fatal despite disrupting the antiviral therapy and initiating a high-dose corticotherapy. This complication of interferon alfa treatment was reported in the literature in only one case. Through this case and a review of the literature, we aim to underline the importance of screening for sarcoidosis before and during the follow-up of HCV patients undergoing antiviral therapy.


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2008 Journal of Global Infectious Diseases | Published by Wolters Kluwer - Medknow
Online since 10th December, 2008