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BIOGEOCHEMICAL SCIENCES
Year : 2010  |  Volume : 2  |  Issue : 2  |  Page : 101-104

Synergistic properties of methylxanthine with cadmium and mercury on dermatophytes


Department of Clinical Laboratory, College of Pharmacy, University of Kerbala, Iraq

Correspondence Address:
Ali Abdul Hussein S AL-Janabi
Department of Clinical Laboratory, College of Pharmacy, University of Kerbala
Iraq
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-777X.62878

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Background: Methylxanthine has many antimicrobial effects on different types of organisms. Synergism actions between methylxanthine and cadmium or mercury on dermatophytes were tested. Aims: To determine the synergistic property between methylxanthine and cadmium or mercury on the growth of dermatophytes. Materials and Methods: Two isolated strains of dermatophytes (Trichophyton mentagrophytes and Epidermophyton floccosum) that clinical isolated were treated with the mixtures of methylxanthine either with cadmium or with mercury by using colony diameter method. Percentage inhibition was also calculated based on perpendicular colony diameters of grown fungi. Results: Cadmium had high ability to increase inhibitory action of methylxanthine agents on dermatophytes. Epidermophyton floccosum revealed more susceptibility to tested mixture than those of Trichophyton mentagrophytes. Mercury exhibited variable effects on dermatophytes after mixing with methylxanthine. Conclusions : Effective concentrations of methylxanthine on dermatophytes decreased in the presence of cadmium and mercury. Variable susceptibility of two species of dermatophytes to prepared mixture was noted.


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2008 Journal of Global Infectious Diseases | Published by Wolters Kluwer - Medknow
Online since 10th December, 2008