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CASE REPORT Table of Contents   
Year : 2009  |  Volume : 1  |  Issue : 2  |  Page : 146-148
Rhabdomyolysis in a child secondary to Staphylococcus aureus endocarditis


1 Department of Paediatrics, Birmingham Children's Hospital, Steelhouse Lane, Birmingham, B4 6NH, United Kingdom
2 Department of Paediatric Cardiology, Birmingham Children's Hospital, Steelhouse Lane, Birmingham, B4 6NH, United Kingdom

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Date of Web Publication3-Oct-2009
 

   Abstract 

Rhabdomyolysis secondary to bacterial infection has only rarely been investigated, and there are case reports of the same mainly in adults. This article describes the first reported case of rhabdomyolysis in a child secondary to Staphylococcus aureus endocarditis. A 12-year-old child presented with myalgia, pyrexia and dark urine and was found to have infective endocarditis due to S. aureus.

Keywords: Endocarditis, Rhabdomyolysis, Staphylococcus aureus

How to cite this article:
Bandi S, Chikermane A. Rhabdomyolysis in a child secondary to Staphylococcus aureus endocarditis. J Global Infect Dis 2009;1:146-8

How to cite this URL:
Bandi S, Chikermane A. Rhabdomyolysis in a child secondary to Staphylococcus aureus endocarditis. J Global Infect Dis [serial online] 2009 [cited 2019 Oct 17];1:146-8. Available from: http://www.jgid.org/text.asp?2009/1/2/146/56250



   Introduction Top


Rhabdomyolysis is the breakdown of muscle fibers, when leakage of potentially toxic cellular contents into the circulation can lead to hypovolemia, acidosis, hyperkalemia, acute renal failure and disseminated intravascular coagulation. [1] An increased plasma concentration of creatine kinase (CK) or myoglobin and the presence of myoglobinuria are useful parameters for diagnosing this disease. Alcohol ingestion, crush injuries and generalised seizures are well-known causes of rhabdomyolysis. [1] Rhabdomyolysis secondary to bacterial infection has only rarely been investigated, and there are case reports of the same mainly in adults. [2],[3],[4],[5],[6],[7],[8],[9],[10],[11]

This article describes the first reported case of rhabdomyolysis in a child secondary to Staphylococcus aureus endocarditis. A 12-year-old child presented with myalgia, pyrexia and dark urine and was found to have infective endocarditis due to S. aureus.


   Case Report Top


A 12-year-old boy was admitted with a 1-week history of pyrexia, myalgia and dark urine. He had history of herpes encephalitis and epilepsy and was not on any other medication apart from carbamazepine for his epilepsy. He did not have any seizures recently, and there was no history of trauma. There was no previous history of muscle disease or muscle weakness. He was completely mobile till the occurrence of this current illness. On examination he was febrile, with a normal capillary refill and blood pressure. He had a few infected blisters on his legs. There were no signs and symptoms suggestive of alcohol intoxication. There was generalized tenderness over his muscles, and he could not bear weight without support because of myalgia. Findings from his neurological examination were completely normal, including tendon reflexes and fundoscopy. He had normal heart sounds with no murmurs, his chest was clear, his abdomen was soft and there was no hepatosplenomegaly.

His urine dipstick showed 3+ blood, and subsequent laboratory testing confirmed it as myoglobin. He had a raised C-reactive protein (CRP) of 225 U/L and a raised creatine kinase of 9982 U/L. He was initially started on cefotaxime, which was changed to more specific flucloxacillin and rifampicin once the initial blood culture grew Staphylococcus aureus (sensitive to flucloxacillin). His creatine kinase reached a peak value of 12156 U/L on day 2 of admission, with a gradual fall over the next few days, reaching a normal level by day 7 of admission. The myalgia improved gradually, he started bearing weight after 2 to 3 days and was completely mobile by day 5 of admission. He remained hemodynamically stable throughout his hospital stay without any evidence of shock. His renal functions were normal, apart from slightly raised urea, viz., 9.4, which settled with adequate intravenous hydration.

On day 4 of admission, he developed a heart murmur; and in view of persisting pyrexia, he underwent an echocardiogram, which showed large vegetation on the septal leaflet of tricuspid valve. Gentamicin was added; however, even after 2½ weeks of intravenous antibiotic therapy, he continued to have high-grade fever. Both the fever and the inflammatory markers settled once the vegetation was surgically removed.

He received antibiotics for a total 6 weeks (4 weeks IV and 2 weeks oral). The vegetation did not grow any bacteria, and the histology was consistent with infective endocarditis. The follow-up echocardiograms have all been normal.


   Discussion Top


The pathogenesis of rhabdomyolysis is not fully understood. However, direct bacterial invasion into muscle, [12] bacterial toxin, [13] metabolic derangements, [13] rigors and fever [14] and nonspecific sepsis-related mechanisms [12],[15],[16] may be precipitating factors that explain muscle injury. Although there is no supporting evidence, it has been suspected that endotoxin or endotoxin-like substances might play a part in the onset of rhabdomyolysis. [6]

In our case, there was no other contributing history to suggest other causes of rhabdomyolysis - there was no history of trauma; he did not have recent seizures; he was not on any known medication that could potentially cause rhabdomyolysis. There was definite clinical (myalgia, muscle tenderness) and biochemical (raised CK) evidence of muscle inflammation. His inability to bear weight was attributed to myalgia as he had normal tendon reflexes and muscle power. Hence a neurology consultation or neuroimaging was not requested. The only contributing factor for rhabdomyolysis in our case was staphylococcal sepsis. His symptoms and signs of rhabdomyolysis improved within 1 week, although he developed further complication of bacterial endocarditis, which required prolonged treatment.

Muscle involvement by S. aureus usually manifests as suppurative myositis - either as a localized large abscess or many small abscesses. This condition has been named "pyomyositis." [17] Rhabdomyolysis has also been noted in patients with toxic shock syndrome, [18],[19],[20],[21] presumably secondary to the effects of exotoxin on the muscle.

Two previous cases of rhabdomyolysis associated with S. aureus have been reported in children without toxic shock. Adamski and co-workers described the case of a 15-year-old boy with nonsuppurative myositis and rhabdomyolysis. [8] The creatine kinase level was 33,400 U/L. Saul and co-workers reported a case of a 13-year-old girl with rhabdomyolysis with a creatine kinase level of 59,729 U/L. She did not have toxic shock syndrome or bacteremia but had staphylococcus organisms isolated from urine. [22]

To the best of our knowledge, there is only one previous case report of rhabdomyolysis in a 20-year-old man who had S. aureus endocarditis. [10] In that case, blood and urine cultures were positive for S. aureus, and the peak creatine kinase level was 990 U/L. To date there are no similar reports in pediatric literature. In our case the blood culture was positive for S. aureus, and echocardiogram demonstrated vegetation, confirming the diagnosis of infective endocarditis. This is probably the most feasible explanation for the child's symptoms. The infected blisters were probably the potential source of his infection, though we haven't grown anything from the blisters. In spite of initial antibiotic treatment, the fever persisted and only settled once the vegetation was surgically removed. Luckily he had only mild derangement of his renal functions but could have potentially had a full-blown renal failure requiring intensive management.

It has been reported that about 33% of patients with rhabdomyolysis develop acute renal failure. [23] However, it is also recognized that myoglobinuria itself does not cause acute renal failure, and the renal dysfunction seems to result from a combination of hypovolemia, hypoxia, endotoxin- or endotoxin-like substances with other events.

Once the diagnosis of rhabdomyolysis is made, adequate hydration and alkalinization of the urine are necessary in order to prevent renal failure. In our patient suitable antibiotic treatment and adequate hydration proved effective in slowing the process of rhabdomyolysis.


   Conclusion Top


We conclude that rhabdomyolysis should be considered as a possible complication in various infections, especially in any child presenting with myalgia and dark urine. Early aggressive management has a good prognosis.

 
   References Top

1.Warrell DA, Cox TM, Firth JD, Benz JE. Oxford textbook of Medicine. 4 th ed. Oxford University Press; 2004.  Back to cited text no. 1      
2.Henrich WL, Prophet D, Knochel JP. Rhabdomyolysis associated with Escherichia coli septicemia. South Med J 1980;73:936.  Back to cited text no. 2      
3.Soule TI, Cunningham GR. Herbicola lathyri septicemia, myoglobinuria, and acute renal failure. JAMA 1973;223:1265-6.  Back to cited text no. 3      
4.Hroncich ME, Rudinger AN. Rhabdomyolysis with pneumococcal pneumonia: A report of two cases. Am J Med 1989;86:467-8.  Back to cited text no. 4      
5.Rheingold OJ, Greenwald RA, Hayes PJ, Tedesco FJ. Myoglobinuria and renal failure associated with typhoid fever. JAMA 1977;238:341.  Back to cited text no. 5      
6.Posner MR, Caudill MA, Brass R, Ellis E. Legionnaires' disease associated with rhabdomyolysis and myoglobinuria. Arch Intern Med 1980;140:848-50.  Back to cited text no. 6      
7.Wu AW, Benirschke K, MacCutchan JA. Rhabdomyolysis and S. aureus septicemia in a man with the acquired immunodeficiency syndrome. West J Med 1990;152:716.  Back to cited text no. 7      
8.Adamski GB, Garin EH, Ballinger WE, Shulman ST. Generalized nonsuppurative myositis with staphylococcal septicemia. J Pediatr 1980;96:694-7.  Back to cited text no. 8      
9.Lannigam R, Austin TW, Vestrup J. Myositis and rhabdomyolysis due to Staphylococcus aureus septicemia. J Infect Dis 1984;150:784.  Back to cited text no. 9      
10.Saitoh H, Yoshii F, Ishihara T, Shinohara Y. Rhabdomyolysis associated with staphylococcal septicemia. Rinsho Shinkeigaku (Clin Neurol) 1986;26:693-7.  Back to cited text no. 10      
11.Bando T, Fujimura M, Noda Y, Ohta G, Hirose J, Matsuda T. Rhabdomyolysis associated with bacteremic pneumonia due to Staphylococcus aureus. Intern Med 1994;33:454-5.  Back to cited text no. 11      
12.Chun CH, Raff MJ. Rhabdomyolysis associated with pneumococcal sepsis. Diagn Microbiol Infect Dis 1985;3:257-61.  Back to cited text no. 12      
13.Friman G, Ilback NG, Beisel WR. Effects of Streptococcus pneumoniae, Salmonella typhimurium and Francisella tularensis infections on oxidative, glycolytic and lysosomal enzyme activity in red and white skeletal muscle in the rat. Scand J Infect Dis 1984;16:111-9.  Back to cited text no. 13      
14.Bywaters EG, Stead JK. The production of renal failure following injection of solutions containing myohaemoglobin. Q J Exp Physiol 1944;33:53-70.  Back to cited text no. 14      
15.Knochel JP. The pathophysiology and clinical characteristics of severe hypophosphatemia. Arch Intern Med 1977;137:203-20.  Back to cited text no. 15      
16.Clowes GH, George BC, Villee CA, Saravis CA. Muscle proteolysis induced by a circulating peptide in patients with sepsis or trauma. NEJM 1983;308:545-52.  Back to cited text no. 16      
17.Armstrong JH. Tropical pyomyositis and myoglobinuria. Arch Intern Med 1978;138:1145-6.  Back to cited text no. 17      
18.McKenna UG, Meadows JA, Brewere NS, Wilson WR, Perrault J. Toxic shock syndrome, a newly recognized disease entity-Report of 11 cases. Mayo Clin Proc 1980;55:663-72.  Back to cited text no. 18      
19.Chesney RW, Chesney PJ, Davis JP, Segar WE. Renal manifestations of the staphylococcal toxic-shock syndrome. Am J Med 1981;71:583-8.  Back to cited text no. 19      
20.Scobie BA. Staphylococcal toxic shock: Two fulminant cases with recovery. NZ Med J 1982;95:145-7.  Back to cited text no. 20      
21.Bachhuber R, Parker RA, Bennet WM. Acute renal failure in toxic shock syndrome owing to rhabdomyolysis. Ann Clin Lab Sci 1983;13:25-6.  Back to cited text no. 21      
22.Saul RA, Vernon M, Roe C, Osoesky SG. Rhabdomyolysis in a patient with nonoliguric renal failure: Similarities to the toxic-shock syndrome. South Med J 1980;73:261-3.  Back to cited text no. 22      
23.Gabow PA, Kaehny WD, Kelleher SP. The spectrum of rhabdomyolysis. Medicine 1982;61:141-52.  Back to cited text no. 23      

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Correspondence Address:
Srinivas Bandi
Department of Paediatrics, Birmingham Children's Hospital, Steelhouse Lane, Birmingham, B4 6NH
United Kingdom
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-777X.56250

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    Abstract
    Introduction
    Case Report
    Discussion
    Conclusion
    References

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2008 Journal of Global Infectious Diseases | Published by Wolters Kluwer - Medknow
Online since 10th December, 2008