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PUBLIC HEALTH RESEARCH
Year : 2009  |  Volume : 1  |  Issue : 2  |  Page : 111-116

Anamnestic immune response to dengue and decreased severity of yellow fever


1 Department of Global Health, College of Public Health, University of South Florida, Tampa, USA
2 Department of Epidemiology and International Health, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA
3 Department of Pathology, Center for Tropical Diseases, University of Texas Medical Branch, Galveston, Texas, USA
4 Ecuadorian Armed Forces Hospital HG-1, Quito, Ecuador, USA
5 Department of Global Health, College of Public Health, University of South Florida, Tampa, Florida, USA
6 Institute for Global Health, School of Medicine, Vanderbilt University, USA

Correspondence Address:
Ricardo O Izurieta
Department of Global Health, College of Public Health, University of South Florida, Tampa
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-777X.56257

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A protective immunity against yellow fever, from cross-reactive dengue antibodies, has been hypothesized as an explanation for the absence of yellow fever in Southern Asia where dengue immunity is almost universal. This study evaluates the association between protective immunity from cross-reactive dengue antibodies with yellow fever infection and severity of the disease. The study population consisted of military personnel of a jungle garrison and its detachments located in the Ecuadorian Amazonian rainforest. The cross-sectional study employed interviews as well as seroepidemiological methods. Humoral immune response to yellow fever, Mayaro, Venezuelan equine encephalitis, Oropouche, and dengue 2 infections was assessed by evaluating IgM and IgG specific antibodies. Log-linear regression analysis was used to evaluate age and presence of antibodies, against dengue type 2 virus, as predictors of yellow fever infection or severe disease. During the seroepidemiological survey, presence of dengue antibodies among yellow fever cases were observed in 77.3% cases from the coastal region, where dengue is endemic, 14.3% cases from the Amazon and 16.7 % cases from the Andean region. Dengue cross-reactive antibodies were not significantly associated with yellow fever infection but significantly associated with severity of the disease. The findings of this study suggest that previous exposure to dengue infection may have induced an anamnestic immune response that did not prevent yellow fever infection but greatly reduced the severity of the disease.


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2008 Journal of Global Infectious Diseases | Published by Wolters Kluwer - Medknow
Online since 10th December, 2008